As it only requires two Bloodgems, the Bloodgem Sword is a recommended beginning weapon. Its infinite durability especially helps, because most Mobs have high health in DivineRPG, so spamming the attack button will not drain the durability bar. The Bloodgem Sword can only be enchanted through the use of an enchanted book & and anvil.
The Massivence is also an important item created with Bloodgems. It does not do any extra damage, but it heals the player by 2 health points (x1) when used (i.e. right-clicked with). It is extremely useful for the Overworld and even the Twilight dimensions.